Version=3.21301
EndTime=5.000000e+003
Points=20000
OutputTimeZero=1
RealTime=0
SleepTime=1
TimeUnit=s
ConcentrationUnit=mM
VolumeUnit=ml
TimeElasticities=0
Dynamics=1
SteadyState=0
Report=1
DynTitles=0
SSTitles=0
DynQuotes=0
SSQuotes=0
DynColWidth=12
SSColWidth=12
DynSeparator=32
SSSeparator=32
SSMCAUnscaled=0
SSStrategy=0
SSBackIntegration=1
RepStructuralAnalysis=0
RepStabilityAnalysis=0
RepMCA=1
NewtonLimit=50
SSResoltion=1.000000e-009
RelativeTolerance=1.000000e-006
AbsoluteTolerance=1.000000e-012
AdamsMaxOrder=12
BDFMaxOrder=5
DerivationFactor=1.000000e-003
ReportFile=repressilator.txt
DynamicsFile=simresults.dyn
SSFile=simresults.ss
Title=Repressilator
TotalMetabolites=12
TotalSteps=18
TotalMoieties=3
TotalCompartments=1
TotalUDKinetics=0
Metabolite=lacI^0
Concentration=0.6
Compartment=0
Type=1
Metabolite=lacI^1
Concentration=0
Compartment=0
Type=2
Metabolite=tetR^0
Concentration=0.7
Compartment=0
Type=1
Metabolite=tetR^1
Concentration=0
Compartment=0
Type=2
Metabolite=cI^0
Concentration=0.8
Compartment=0
Type=1
Metabolite=cI^1
Concentration=0
Compartment=0
Type=2
Metabolite=cI^p
Concentration=0
Compartment=0
Type=1
Metabolite=lacI^p
Concentration=0
Compartment=0
Type=1
Metabolite=tetR^p
Concentration=0
Compartment=0
Type=1
Metabolite=lacI^r
Concentration=0
Compartment=0
Type=1
Metabolite=tetR^r
Concentration=0
Compartment=0
Type=1
Metabolite=cI^r
Concentration=0
Compartment=0
Type=1
Metabolite=  tetR^0 + tetR^1 
Concentration=0.7
Compartment=0
Type=7
Metabolite=  lacI^0 + lacI^1 
Concentration=0.6
Compartment=0
Type=7
Metabolite=  cI^0 + cI^1 
Concentration=0.8
Compartment=0
Type=7
Step=R1
Equation=lacI^0 = lacI^1
KineticType=Mass action (reversible)
Flux=0
Reversible=1
Substrates=1
Products=1
Modifiers=0
Constants=2
Subs0=0
Prod0=1
Param0=0.01
Param1=0
Step=R2
Equation=tetR^0 = tetR^1
KineticType=Mass action (reversible)
Flux=0
Reversible=1
Substrates=1
Products=1
Modifiers=0
Constants=2
Subs0=2
Prod0=3
Param0=0.01
Param1=0
Step=R3
Equation=cI^0 = cI^1
KineticType=Mass action (reversible)
Flux=0
Reversible=1
Substrates=1
Products=1
Modifiers=0
Constants=2
Subs0=4
Prod0=5
Param0=0.02
Param1=0
Step=R4
Equation=lacI^1 + cI^p = lacI^0
KineticType=Mass action (reversible)
Flux=0
Reversible=1
Substrates=2
Products=1
Modifiers=0
Constants=2
Subs0=1
Subs1=6
Prod0=0
Param0=2
Param1=0.05
Step=R5
Equation=tetR^1 + lacI^p = tetR^0
KineticType=Mass action (reversible)
Flux=0
Reversible=1
Substrates=2
Products=1
Modifiers=0
Constants=2
Subs0=3
Subs1=7
Prod0=2
Param0=2.5
Param1=0.05
Step=R6
Equation=cI^1 + tetR^p = cI^0
KineticType=Mass action (reversible)
Flux=0
Reversible=1
Substrates=2
Products=1
Modifiers=0
Constants=2
Subs0=5
Subs1=8
Prod0=4
Param0=2
Param1=0.05
Step=R7
Equation=lacI^1 = lacI^1 + lacI^r
KineticType=Mass action (reversible)
Flux=0
Reversible=1
Substrates=1
Products=2
Modifiers=0
Constants=2
Subs0=1
Prod0=1
Prod1=9
Param0=1
Param1=0
Step=R8
Equation=tetR^1 = tetR^1 + tetR^r
KineticType=Mass action (reversible)
Flux=0
Reversible=1
Substrates=1
Products=2
Modifiers=0
Constants=2
Subs0=3
Prod0=3
Prod1=10
Param0=1
Param1=0
Step=R9
Equation=cI^1 = cI^1 + cI^r
KineticType=Mass action (reversible)
Flux=0
Reversible=1
Substrates=1
Products=2
Modifiers=0
Constants=2
Subs0=5
Prod0=5
Prod1=11
Param0=1
Param1=0
Step=R10
Equation=lacI^r = lacI^r + lacI^p
KineticType=Mass action (reversible)
Flux=0
Reversible=1
Substrates=1
Products=2
Modifiers=0
Constants=2
Subs0=9
Prod0=9
Prod1=7
Param0=0.002
Param1=0
Step=R11
Equation=tetR^r = tetR^r + tetR^p
KineticType=Mass action (reversible)
Flux=0
Reversible=1
Substrates=1
Products=2
Modifiers=0
Constants=2
Subs0=10
Prod0=10
Prod1=8
Param0=0.002
Param1=0
Step=R12
Equation=cI^r = cI^r + cI^p
KineticType=Mass action (reversible)
Flux=0
Reversible=1
Substrates=1
Products=2
Modifiers=0
Constants=2
Subs0=11
Prod0=11
Prod1=6
Param0=0.002
Param1=0
Step=R13
Equation=lacI^r = 
KineticType=Mass action (reversible)
Flux=0
Reversible=1
Substrates=1
Products=0
Modifiers=0
Constants=2
Subs0=9
Param0=0.02
Param1=0
Step=R14
Equation=tetR^r = 
KineticType=Mass action (reversible)
Flux=0
Reversible=1
Substrates=1
Products=0
Modifiers=0
Constants=2
Subs0=10
Param0=0.02
Param1=0
Step=R15
Equation=cI^r = 
KineticType=Mass action (reversible)
Flux=0
Reversible=1
Substrates=1
Products=0
Modifiers=0
Constants=2
Subs0=11
Param0=0.02
Param1=0
Step=R16
Equation=lacI^p = 
KineticType=Mass action (reversible)
Flux=0
Reversible=1
Substrates=1
Products=0
Modifiers=0
Constants=2
Subs0=7
Param0=0.02
Param1=0
Step=R17
Equation=tetR^p = 
KineticType=Mass action (reversible)
Flux=0
Reversible=1
Substrates=1
Products=0
Modifiers=0
Constants=2
Subs0=8
Param0=0.02
Param1=0
Step=R18
Equation=cI^p = 
KineticType=Mass action (reversible)
Flux=0
Reversible=1
Substrates=1
Products=0
Modifiers=0
Constants=2
Subs0=6
Param0=0.02
Param1=0
Compartment=compartment
Volume=1.000000e+000
Comments

EndComments
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PlotDyn=0
Plot3d=0
PlotGrid=1
PlotKey=0
PlotTitles=1
PlotMultiplot=0
PlotContour=0
PlotHidden3d=0
PlotLogX=0
PlotLogY=0
PlotLogZ=0
PlotXEntry=1
PlotYTotal=1
PlotZTotal=1
PlotY0=2
PlotZ0=-1
User-defined functions
Items=0
Interactive time course
Items=0
Time-course output
Items=3
Title=time
Type=14
Title=real time
Type=23
Title=[tetR^r]t
Type=3
I=tetR^r
Steady-state output
Items=0
Scan
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Dimension=0
Parameter Links
Items=0
Optimisation
Enabled=0
SetModel=0
Sign=1.0
OptimiseDyn=1
Constrained=0
Method=Evolutionary programming
P0=500
P1=10
P2=1
P3=1
P4=1
Title=
Type=0
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FitDyn=1
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FitDataFile=
FitSeparator=32
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Method=Evolutionary programming
P0=500
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